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食品科学与工程教研室
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赵旭
日期:2019-03-25 15:55:59 来源:功能食品与葡萄酒学院

个人简介

赵旭,男,1983年生,药学博士,副教授,硕士生导师。2016年1月起,在功能食品与葡萄酒学院任教、从事科研工作,同年12月,被聘为赌钱网站365副教授。2018年入选辽宁省第十二批“百千万人才工程”万人层次,获沈阳市高层次人才“拔尖人才”称号。作为课题负责人主持国家自然科学基金青年基金项目1项,主持其他省部级以上课题2项。相关研究成果已发表SCI论文20余篇,其中第一或通讯作者SCI论文7篇。获得沈阳市学术成果奖2项。

主要研究方向:中药、功能食品药效物质基础研究;神经退行性疾病活性成分筛选及中药干预;高血脂症、高尿酸血症等代谢性疾病活性成分筛选及作用机制研究。

主持的科研项目:

1.基于活性筛选和谱效表征的益智仁抗阿尔茨海默病药效物质基础研究,国家自然科学基金青年科学基金项目(负责人)

2.酸枣仁黄酮改善学习记忆的作用机制和谱效关系表征,辽宁省教育厅项目(负责人)

3.基于谱效表征和信号通路的栀子豉汤抗抑郁作用机制研究,中国博士后科学基金(负责人)

4.栀子豉汤抗抑郁活性成分的筛选与治疗药物的开发,天津市企业博士后创新项目择优资助计划(负责人)

近年来发表代表性论文:

1.Xu Zhao, Xin Su, Chunmei Liu, Ying Jia*, Simultaneous Determination of Chrysin and Tectochrysin from Alpinia oxyphylla Fruits by UPLC-MS/MS and Its Application to a Comparative Pharmacokinetic Study in Normal and Dementia Rats. Molecules, 2018, 23, 1702. (IF: 3.098)

2.Xu Zhao, Zhengzheng Liao, Yu Qi, Xu Shen, Kaishun Bi, Ying Jia*, Antioxidative activity of methyl amygdalinate from the seeds of Prunus persica and neuroprotective effects on Aβ1-42-induced neurodegeneration models. RSC Advances, 2016, 6, 93794-93800. (IF=3.108)

3.Xu Zhao, Chunmei Liu, Mengjie Xu, Xiaolong Li, Kaishun Bi, Ying Jia*, Total lignans of Schisandra chinensis ameliorates Aβ1-42-induced neurodegeneration with cognitive impairment in mice and primary mouse neuronal cells. Plos One, 2016, 11(4): e0152772. (IF=2.806)

4.Xu Zhao, Chunmei Liu, Yu Qi, Lina Fang, Jie Luo, Kaishun Bi, Ying Jia, Timosaponin B-II ameliorates scopolamine-induced cognition deficits by attenuating acetylcholinesterase activity and brain oxidative damage in mice. Metabolic Brain Disease, 2016, 31, 1455-1461. (IF=2.297)

5. Lina Fang, Qiudi Wang, Kaishun Bi,Xu Zhao*, Simultaneous Determination of Procaspase Activating Compound 1 and Permeability Markers in Intestinal Perfusion Samples and Application to a Rat Intestinal Absorption Study. Chromatographia, 2016, 79, 1659-1663. (IF=1.402)

6.Xu Zhao, Xin Mao, Xuan Xu, Xiaolong Li, Kaishun Bi, Ying Jia*, Determination and pharmacokinetics of linarin in rat plasma after intramuscular administration of linarin solution and Yejuhua injection by HPLC. Biomedical Chromatography, 2015, 29:164-166. (IF=1.729)

7.Xu Zhao, Tiancheng Ma, Chenning Zhang, Shaohuai Shi, Sijiao Cui, Kaishun Bi, Ying Jia*, Simultaneous determination of senkyunolide I and senkyunolide H in rat plasma by LC-MS: application to a comparative pharmacokinetic study in normal and migrainous rats after oral administration of Chuanxiong Rhizoma extract. Biomedical Chromatography, 2015, 29, 1297-1303. (IF=1.729)